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For example, the C-terminal tyrosine residue is particularly critical because it significantly promotes tyrosine binding and inhibition by changing the conformation of the enzyme (Kose and Oncel, 2022)

Observed responses in research settings are generally mild and may include temporary administration-site irritation, redness, warmth sensations, local sensitivity, temporary itching, mild fatigue, or response variability depending on research amount, administration frequency, protocol duration, and individual sensitivity